Health Data Tip

Allergy symptoms are caused by excess immune reaction. The IgE type antibody is related by about 70 to 80% to allergy symptoms. The IgE antibody was originally for parasites and is the immunological allergic reaction generated against non-infective foreign substances (including pollen, dust), accompanied by inflammation.

For patients with allergic symptoms, the Tred cell, producing TGF-beta, withers and finally reduces the generation of IgA. This has now been verified through clinical tests.

It is widely known that powerful lactobacilli keep intestines healthy by normalizing the microflora distorted for various reasons inside the intestines.

Powerful lactobacilli help to inhibit intestinal infection by prompting immune reaction (IL-10 and TGF-b) for infectious microorganisms penetrating the intestines, creating IgA antibody and producing anti-microbial substances. The results indicate that powerful live Kimchi lactobacilli can inhibit allergies.

A fundamental treatment is more important. When the immune system loses its balance, allergy, atopy, hives, itching, rhinitis or asthma occurs. We could manage such symptoms as antibodies against antigens from nature including soil, plant, air or water were created when we were freely immersed in nature in the past. However, a number of scientists have found that allergy, atopy or itching are caused as the immune system, the most important controller in the intestines, has lost its balance because we live in a fixed environment--civilized society--with less opportunity to come in contact with nature.

Good news for atopy! Treatment cases are ongoing.

See the following.

Dry skin in patients suffering from atopic dermatitis increases itching by more than twice and makes skin vulnerable to infection.

Ceramide on the epidermis helps the skin to retain moisture. Atopic dermatitis sufferers have less ceramide in their skin than healthy people. Their skin lacks the enzyme generating ceramide because of abnormal ceramide synthesis and bacterial infection. The precursor of ceramide is created but the ceramide itself is not made.

The allergen is the causative substance causing an allergy. It is accompanied by severe itching. Lactobacilli controls macrophage killing pathogens penetrating from the outside. Macrophages prevent allergies by controlling the T cell generating antibodies and killing the virus or cancer cells.

 
Lactobacilli was orally administered to children suffering from atopic dermatitis and interferon gamma secretion increased. It inhibited the secretion of cytokines increasing the antibodies causing the allergy. Interlukin-4 is also a kind of cytokine including the production of antibodies (IgE) causing the allergy.

Accordingly, it is necessary to inhibit the secretion of interlukin-4 to eliminate the allergy. In other words, the secretion of interlukin-4 was inhibited by powerful lactobacilli. (Source: Lactobacilli-making fermented food saved me. Pyeonaem. The first impression of first edition printed on July 1, 2007.)

The Lactobacillus Plantarum k-1 of Bio Rhythm, the powerful Kimchi lactobacilli of Bio Rhythm coated in 3 steps, improves and treats diseases including allergic disease, atopic dermatitis, rhinitis and itching.

The Lactobacillus Plantarum k-1 of Bio Rhythm is a remarkable product winning the Commissioner’s Prize of the Korean Intellectual Property Office in the Korea Invention Patent Exhibition, and the Technology Innovation Prize from the Small and Medium Enterprise Innovation Association of Korea.

Its remarkable function appears 2 weeks at the latest after taking it when treatment starts.

-The following are cases after taking the Lactobacillus Plantarum k-1 of Bio Rhythm)-

Something unbelievable happened to me. I am 21 years old and study in a college. I heard in the mass media that lactobacilli were effective against atopy about one year ago. My parents had a hard time in caring for me since I was young and felt as painful as I felt when watching me. Our life was a series of pain. Itching and scars were always here and there on my body. It was really irritating. I was devastated by pain and stress that I couldn’t endure. I tried the western or oriental medicines that were said to be effective, folk remedies recommended by my acquaintances and relatives and everything that people said was good in treating atopy, including some really awful stuff. By chance, a friend of my aunt called me when the winter holiday started last year. She said she used Kimchi lactobacilli because of constipation and intestinal troubles. She thought Kimchi lactobacilli would be good even for skin because constipation would be treated and the intestines would be changed. I met her in the COEX exhibition hall in Oct. last year. She said Kimchi lactobacilli was very effective for her. She also said the research on the effect of the specific Kimchi lactobacilli against atopy had been presented in an international journal. Thanks to my mom, I ate sour yogurt for seven months, long enough to be tired of it. My mom prepared yogurt every night for me. I took very bitter oriental medicine because of the lack of effect from the yogurt. My mom had a hard time preparing different materials for me. I couldn’t believe that anything was effective. I had tried yogurt and even lactobacilli directly by making yogurt at home. I was not sure but I tried the Kimchi lactobacilli while thinking it would be another trick. But, gosh! My body changed 3 weeks after taking the Kimchi lactobacilli, Lactobacillus Plantarum k-1. I took two spoonfuls of Lactobacillus Plantarum k-1 right after meals. I took more when I got stressed from study. I felt my intestines becoming more comfortable within 1 or 2 days after taking the lactobacilli. I cleared my bowels every morning with thick excretion. While I felt comfortable with my organs because my intestines were cleared out every day, I felt a little bit hungry. The greatest inconvenience was frequent gas for a few days after I started taking the Lactobacillus Plantarum k-1. I unconsciously passed gas and I hated it. But fortunately, it had no smell. The miracle began 2 weeks after starting the Lactobacillus Plantarum k-1. The itching that had tormented me for 11 years gradually disappeared and scars made by scratching disappeared including around my neck and behind my knees. I am very grateful to the friend of my aunt living in Sillim-dong. I also thank the researchers at Bio Rhythm. I would like to strongly recommend Lactobacillus Plantarum k-1. to those who suffer from atopy and itching. ---Seok Dahye in Dongdeok-dong – Feb. 19, 2013.

-Summary -

L. plantarum K-1(LP), lactobacillus inhibiting the activation of AP-1 and NF-ΚB, was separated from Kimchi and applied to a mouse to identify the inhibitory activity against itching and hypersensitivity of skin. LP significantly activated NF-κB and c-jun, the transcription factors, in the RBL-2H3 cell (rat basophilic leukemia) stimulated by phorbol 12'-myristate 13'-acetate (PMA) and inhibited the expression of TNF-α and IL-4. Furthermore, LP demonstrated a strong inhibitory effect against the positive hypersensitivity of skin stimulated in a mouse by the IgE-antigen. When LP was administered to mice, 1x1010 per mouse, the hypersensitivity of the mice was inhibited by up to 87.5%. When LP was administered to mice, 1×1010 CFU per mouse, itching induced by histamine was inhibited by up to 58.9%. LP substantially inhibited osmosis into the blood caused by the histamine. The effect was directly proportionate to the effect of inhibiting itching. LP ( 1×1010 CFU) inhibited the expression of IL-4, IL-1β and TNF-α caused by histamines by 88.9%, 88.6% and 98.9%, respectively. LP inhibited IgE induced by histamines by 85.3%. As a result, LP demonstrated an anti-allergic effect by controlling the expression of IgE-switching cytokine IL-4, proinflammatory cytokines IL- 1β and TNF-α by inhibiting the activation of NF κB and AP-1, the transcription factors in the immune cells, and treated diseases including allergic diseases, atopic dermatitis, rhinitis and itching.

High-tech bioengineering has been significantly advanced up to the present. The following are quoted from recently-published international journals.

.Inhibitory Effect of Lactobacillus plantarum K-1 on Passive Cutaneous Anaphylaxis Reaction and Scratching Behavior in Mice (Effect of Lactobacillus Plantarum K-1 on the Treatment of Atopy, Allergy, Rhinitis and Itching) – Published as a thesis in the international research journal and listed in the journal.
Se-Eun Jang1, Hien-Trung Trinh2, Yong-Hyun Chung3, Myung Joo Han1 and Dong-Hyun Kim2,* 1Department of Food and Nutrion, and 2Department of Life and Pharmaceutical Sciences, Kyung Hee University, 1, Hoegi, Dongdaemun-ku, Seoul, 130-701, Korea 3Biorhythm Co., 685-1, Yangcheongri, Ochang-gun, Choongchungbook-do, 363-883, Korea Running title: Anti-allergic effect of Lactobacillus plantarum K-1 *Correspondence Prof. Dr. Dong-Hyun Kim, College of Pharmacy, Kyung-Hee University, 1, Hoegi, Dongdaemun-ku, Seoul 130-701, Korea :

Arch Pharm Res Vol 34, No 12, 2117-2123, 2011, DOI 10.1007/s12272-011-1215-8

Lactobacilli treat skin diseases by activating the immune system of the intestinal tract. It is useless to care for skin that appears damaged when the cause is in the intestines. Change the immune system of the intestines, and the pain will disappear.

The Lactobacillus Plantarum k-1 of Bio Rhythm has a highly remarkable effect in treating atopy, allergy, rhinitis and itching by intake of Kimchi lactobacilli.

Accordingly, the best food for treating atopy is the food made by our mothers with endeavor and love, which is processed in a hygienic way.

When lactobacilli like Lactobacillus Plantarum K-1 of Bio Rhythm, which works intensely in the intestines, is added, a healing miracle is realized.